QC was performed separately on samples of European and African ancestries separately. Variants that failed the Hardy–Weinberg equilibrium test in controls (p-value ≤ 1E-5) or had low call rate (≤95%).

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We applied quality control criteria (call rate of ≥0.99 in both cases and controls and Hardy-Weinberg equilibrium test P of ≥1.0 × 10 −6 in the control population); 430,963 SNPs on all chromosomes.

We applied quality control criteria (call rate of ≥0.99 in both cases and controls and Hardy-Weinberg equilibrium test P of ≥1.0 × 10 −6 in the control population); 430,963 SNPs on all chromosomes.

QC was performed separately on samples of European and African ancestries separately. Variants that failed the Hardy–Weinberg equilibrium test in controls (p-value ≤ 1E-5) or had low call rate (≤95%).

Sample and SNP QC were carried out within each replication data set, using an 80% sample call rate and a 90% SNP call rate threshold, and a Hardy–Weinberg equilibrium threshold of 10 −4. Five samples.

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Sample and SNP QC were carried out within each replication data set, using an 80% sample call rate and a 90% SNP call rate threshold, and a Hardy–Weinberg equilibrium threshold of 10 −4. Five samples.

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